Table 2. Plasma levels of complement components in different pathological variants of primary FSGS patients.
Pathological variant | Plasma levels of complement components (median, IQR) | ||||||
---|---|---|---|---|---|---|---|
C1q (μg/ml) | MBL (ng/ml) | Bb (μg/ml) | C4d (μg/ml) | C3a (ng/ml) | C5a (ng/ml) | C5b-9 (ng/ml) | |
Tip variants | 76.31 | 106.16 | 0.57 | 13.82 | 512.12 | 9.60 | 392.64 |
(n = 23) | (71.35–88.87) | (55.70–217.56) | (0.39–0.77) | (10.51–20.19) | (133.01–954.44) | (7.00–11.68) | (318.21–497.38) |
Nos variants | 84.10 | 96.36 | 0.57 | 16.27 | 497.85 | 9.11 | 336.13 |
(n = 23) | (73.24–104.22) | (34.02–180.32) | (0.37–0.79) | (11.61–21.74) | (357.27–1062.41) | (6.18–19.81) | (267.21–180.32) |
Cellular variants | 66.80 | 99.49 | 0.55 | 13.78 | 654.57 | 13.90 | 513.92 |
(n = 21) | (58.49–8369) | (40.50–170.25) | (0.31–1.18) | (10.16–18.55) | (339.52–1056.99) | (9.00–17.99) | (376.10–784.76) |
P value | |||||||
Total | 0.022 | 0.548 | 0.995 | 0.699 | 0.643 | 0.132 | 0.003 |
tip vs. NOS | 0.132 | 0.047 | |||||
tip vs. cellular | 0.181 | 0.076 | |||||
NOS vs. cellular | 0.006 | 0.001 |
IQR: inter-quartile range; NOS: not otherwise specified.