Figure 1. Enriched pathways of upregulated genes in patients surviving with native livers.

Gene expression data for 171 patients with biliary atresia were divided into 2 groups: (a) survival with native liver at 2 years of age and (b) transplant or death before 2 years. Differentially expressed genes were identified by Cuffdiff 2, with the fold-change cutoff at 1.5 or higher and Benjamini-Hochberg FDR-adjusted P < 0.05. The list of genes upregulated in the survival group were further subjected to functional enrichment analysis shown above, with the top 5 significantly enriched pathways in red being related to erythrocyte pathobiology.