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. 2020 Jun 4;5(11):e137189. doi: 10.1172/jci.insight.137189

Figure 4. Defective resolution in Ch25h-null mice arises from LXR insufficiency.

Figure 4

(A and B) Mice of the indicated genotypes were pretreated i.p. with either synthetic LXR agonist GW3965 (A) or 25HC (B) (or vehicle [Veh] control), exposed to inhaled LPS, and then evaluated for airway PMN count 48 hours later (n = 5/genotype/time point). (C and D) Airway PMNs were quantified in mice of the indicated genotypes at various times following inhalation of LPS (n = 5–8/genotype/time point). Data are mean ± SEM and are representative of 2–3 independent experiments. *P < 0.05; **P < 0.01 by unpaired t test.