Figure 1.

Central carbon metabolism and Ehrlich pathway for synthesizing 2-PE in Y. lipolytica. l-Phe, l-phenylalanine; PPY, phenylpyruvate; PAH, phenylacetaldehyde; GapY3, l-phenylalanine specific permease; ylARO8, l-phenylalanine transaminases; ylHPD, 4-hydroxyphenylpyruvate dioxygenase; ylPHA2, prephenate dehydratase; ylARO10, phenylpyruvate decarboxylase; ylPAR4, phenylacetaldehyde reductases; ALD2,3, aldehyde dehydrogenase; G6P, glucose-6-phosphate; F6P, fructose 6-phosphate; GAP, glyceraldehyde-3-phosphate; 3PG, 3-phospho-glycerate; PEP, phosphoenolpyruvate; aKG, 2-oxoglutarate; DAHP, 3-deoxy-arabino-heptulonate-7-phosphate; SHIK, shikimate ; S3P, shikimate-3-phosphate; l-Tyr, l-tyrosine; l-Typ, L-tryptophan; ARO3,4, 3-deoxy-7-phosphoheptulonate synthase; ylODC, 2-oxodicarboxylate carrier; ylIDP2, cytosolic isocitrate dehydrogenase; EcoacnA, aconitate hydratases; DGA1,2, diacylglycerol acyltransferase;