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. 2020 Jun 4;9:e53470. doi: 10.7554/eLife.53470

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© 2020, Menon et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 1. — (A) Main components of human insula microstructure analysis using diffusion magnetic resonance imaging (dMRI) data from 413 Human Connectome Project (HCP) participants. Key steps include: (i) measurement of microstructure features based on Return to Origin Probability (RTOP), the ratio between the probability of molecules returning to their starting position in biological tissue versus free diffusion, (ii) demarcation of functional subdivisions in insula and its interconnected anterior cingulate cortex (ACC) subdivisions, which together anchor the salience network, (iii) computation of microstructure features of the insula within its functional subdivisions and its interconnected ACC subdivisions, (iv) computation of microstructural gradients along the anterior-posterior and dorsal-ventral axes of the insula, and (v) analysis of relation between insula microstructural organization and cognitive control abilities.