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. 2020 Jun 22;9:e56694. doi: 10.7554/eLife.56694

Figure 7. Microstimulation effects on coordination depended on neural selectivity and baseline adjustments of drift and bound.

(A and B) Principal components (PCs) were estimated for reward context modulation of Δdrift and Δbound without microstimulation (left panels; mean subtracted) for the two monkeys separately. The values of Δdrift (rew × estim) and Δbound (rew × estim) were projected onto these two PCs (right panels). (C) Visualization of the dependence of rew × estim effects on neural selectivity and reward effects without microstimulation for sites with combined modulations by motion coherence and reward context (top) and for other sites (bottom). Proj1(2): projection onto PC1(2). Each row shows the results from one multiple linear regression, with the quantity on the ordinate as the dependent variable and the quantities on the abscissa as the independent variables. Significance was assessed with bootstrap methods using 1000 shuffles of the independent variables. The number in each box indicates the number of shuffles with the same or stronger effect as the experimental data (e.g., six means an estimated p value of 0.006 and 0 means an estimated p value of < 0.001). Colors indicate the signs of regression coefficients (significance criterion: p<0.0125 = 0.05/4-regressions). (D) Percent explained variance for the regressions in (C), respectively. A black bar indicates that the experimental value is outside the 95 percentile of the bootstrapped distribution.

Figure 7—source data 1. Neural selectivity for different task factors at the microstimulation sites.
Column “indRewcontCoh” was used to divide the two subsets of stimulation sites in C and D. PCA was performed on DDM fitting results in Figure 5—source data 1.

Figure 7.

Figure 7—figure supplement 1. MRI reconstruction of recording and microstimulation sites.

Figure 7—figure supplement 1.

(A) Recording and microstimulation sites projected on coronal slices. AC: anterior commissure. Positive numbers: anterior to AC. Negative numbers: posterior to AC. Scale bars: 5 mm. (B) Summary of microstimulation sites, flattened along the Anterior-Posterior axis. Red: sites with significant rew × estim effects on choice, based on logistic fits. Same sites as colored dots with significant y-axis values in Figure 3—figure supplement 1, B1 and B2. (C) Same format as B. Red: sites with significant rew × estim effects on RT, based on linear fits. Same sites as colored dots with significant y-axis values in Figure 3—figure supplement 1, B3-B6. (D) microstimulation sites color-coded by the ranks of ∆drift (rew x estim) (top) and ∆bound (rew x estim) (bottom). Small vertical lines in the color bars indicate zero crossing.