Table 3.

Results of Primary and Secondary Endpoints for Evaporative (EDE) and Non-Evaporative Dry Eye (NEDE) Groups

	EDE Group (N=54)				NEDE Group (N=18)
Endpoints	Total	Mean±SD		P§	Total	Mean±SD		P§
		VSE	CTN			VSE	CTN
TBUT (sec)
Baseline	3.3±1.6	3.3±1.6			2.9±1.1	2.9±1.2
Intermediate visit	4.6±1.8	4.6±1.8**	4.6±1.8**	0.08	4.1±2.4	4.1±2.4*	4.1±2.4*	0.29
Final visit	6.0±2.8	5.6±2.4**	6.5±2.8**	0.74	4.6±2.4	4.6±2.3*	4.6±2.6*	0.30
OSDI questionnaire score
Baseline	39±13	39±13			32±8	32±8
Intermediate visit	24±15	24±15**	24±15**	0.44	20±15	20±15*	20±15*	0.46
Final visit	20±13	20±15**	20±15**	0.38	18±12	18±11**	18±14*	0.49
Schirmer I test (mm/5 min)
Baseline	16±5	16±5			16±6	16±6
Intermediate visit	16±8	16±8	16±8	0.38	14±9	14±9	14±9	0.44
Final visit	14±9	15±9	14±9	0.34	16±10	17±11	16±10	0.40
Complete blinkings (N/min)
Baseline	16±13	16±13			9±5	9±5
Intermediate visit	19±10	19±10	19±10	0.43	11±8	11±8	11±8	0.46
Final visit	22±18	20±15	25±21	0.81	8±5	7±4	9±6	0.77
Incomplete blinkings (N/min)
Baseline	7±6	7±6			11±9	11±9
Intermediate visit	5±5	5±5	5±5	0.37	3±3	3±3*	3±3*	0.40
Final visit	3±4	4±5	2±2**	0.005	3±4**	5±4*	1±2	0.04
Total blinkings (N/min)
Baseline	23±12	23±12			20±13	20±13
Intermediate visit	24±13	24±13	24±13	0.45	13±7	13±7	13±7	0.45
Final visit	25±17	24±15	27±20	0.68	11±6**	13±6*	10±6**	0.22
Osmolarity (mOsm/L)
Baseline	313±20	313±20			318±30	318±30
Intermediate visit	309±15	309±15	309±15	0.47	296±17	296±17	296±17	0.48
Final visit	305±15	307±14	303±17	0.26	308±23	299±18	318±26	0.85

Notes: ^§Paired T-test to compare two treatment group, adjusting by baseline value. *T-test vs baseline, p<0.05. **T-test vs baseline, p<0.001.

Abbreviations: CTN, Cationorm; VSE, VisuEvo.