Table 3.

Correlation of Serum HER2 Level with Imaging Diagnosis

		Imaging Diagnosisb				κ	p value
		Unchanged	Aggravation	Remission	Total
Serum HER2a	Unchanged	197	55	11	263	0.48	<0.001
	Increased	25	81	1	107
	Decreased	15	4	31	50
	Total	237	140	43	420

Notes: ^aThe change of serum HER2 levels within 25% is defined as “Unchanged”; “Increased”: at least 25% increase before treatment; “Decreased”: at least 25% decrease than before treatment. ^bTumor volume (imaging diagnosis) changes within 20% are defined as “Unchanged”; “Aggravation”: at least a 20% increase since treatment started; “Remission”: at least a 20% decrease since treatment started.

Abbreviation: κ, weighted kappa index.