. 2020 Jun 18;12:4677–4684. doi: 10.2147/CMAR.S244606

Table 3.

Associations of RARβ Methylation with the Risk of Breast Cancer in the Current Study and the Validation Study

Independent Variable	Current Study
Independent Variable	OR (95% CI)	P-value
RARβ	2.53 (1.92, 3.35)^a	<0.001*
RARβ	2.67 (2.01, 3.55)^b	<0.001*
	Validation study
	OR (95% CI)	P-value
RARβ MRS	2.82 (1.99, 4.00)^a	<0.001*
RARβ MRS	3.05 (2.12, 4.38)^c

Notes: MRS was constructed using RARβ methylation at cg24396624 and cg26786980. The greater MRS was defined as a score being higher than the median.

^aCrude OR and 95% CI; ^bAdjusted for age, education, age at menarche, parity, menopause status and family history of BC; ^cAdjusted for age and age at menarche; *Indicates statistical significance at 5%.

Abbreviations: RARβ, retinoid acid receptor beta; OR, odds ratio; CI, confidence interval; MRS, methylation risk score.