Table 1.
Baseline Characteristics
| Characteristic | No. (%) of Cases* (n = 69) |
|---|---|
| Sex | |
| Male | 33 (48) |
| Female | 36 (52) |
|
| |
| Age (years) (mean ± SD) | 62.0 ± 14.1 |
|
| |
| Weight (kg) (mean ± SD) | 88.6 ± 20.2 |
|
| |
| BMI (mean ± SD) | 31.3 ± 6.6 |
|
| |
| Risk factors | 66 (96) |
| Diabetes mellitus | 27 (39) |
| Vascular insufficiency | 11 (16) |
| Rheumatic disease† | 30 (43) |
| Immunocompromise | 9 (13) |
| Medication | 4 (6) |
| Malignancy | 5 (7) |
| Chronic kidney disease | 4 (6) |
| Chronic liver disease | 2 (3) |
| IV drug use | 3 (4) |
| Obesity (BMI ≥ 30) | 34 (49) |
| Peripheral neuropathy | 9 (13) |
| Prosthetic material in infected area | 34 (49) |
| History of bone or joint infection | 24 (35) |
| Trauma | 10 (14) |
| Intra-articular corticosteroid injection | 2 (3) |
| Chronic limb ulcer | 17 (25) |
|
| |
| Diagnosis | |
| Prosthetic joint infection | 18 (26) |
| Hip | 6 (9) |
| Knee | 11 (16) |
| Other | 1 (1) |
| Osteomyelitis | 29 (42) |
| Septic arthritis | 5 (7) |
| Diskitis/vertebral osteomyelitis | 17 (25) |
|
| |
| Recurrent infection | 20 (29) |
|
| |
| Culture results | |
| Monomicrobial | 37 (54) |
| Polymicrobial | 18 (26) |
| No growth | 9 (13) |
| Culture information unavailable | 5 (7) |
|
| |
| Microorganism(s) isolated | |
| MSSA | 31 (45) |
| MSSA + other organism(s) | 8 (12) |
| Coagulase-negative staphylococci | 2 (3) |
| Streptococcus mitis | 2 (3) |
| MRSA | 0 (0) |
| Other | 26 (38) |
BMI = body mass index (calculated as weight in kilograms divided by height in meters squared), MRSA = methicillin-resistant Staphylococcus aureus, MSSA = methicillin-susceptible Staphylococcus aureus, SD = standard deviation
*
Except where indicated otherwise. The 69 patient cases represented a total of 68 patients; 1 patient had 2 separate courses of therapy that qualified for inclusion.
†
Rheumatic disease includes rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and psoriatic arthritis.