Table 2.
Cefazolin and Probenecid Prescribing Patterns and Related Treatment
| Prescribing Patterns and Related Treatment | No. (%) of Cases* (n = 69) |
|---|---|
| Cefazolin and probenecid dose and frequency | |
| Cefazolin 2 g IV bid with probenecid 1 g PO bid | 67 (97) |
| Cefazolin 1 g IV bid with probenecid 1 g PO bid | 1 (1) |
| Cefazolin 2 g IV daily with probenecid 1 g PO daily | 1 (1) |
|
| |
| Duration of cefazolin and probenecid therapy (days) (mean ± SD) | |
| All diagnoses | 36.0 ± 16.1 |
| Prosthetic joint infection | 42.9 ± 22.9 |
| Osteomyelitis | 33.7 ± 11.8 |
| Septic arthritis | 23.2 ± 13.3 |
| Diskitis/vertebral osteomyelitis | 36.4 ± 12.2 |
|
| |
| Duration of IV antibiotic therapy before cefazolin and probenecid (days) (mean ± SD) | 11.0 ± 10.0 |
|
| |
| Antimicrobial therapy related to bone or joint infection, concurrent with cefazolin and probenecid | 9 (13) |
| Rifampin | 5 (7) |
| Metronidazole | 3 (4) |
| Ciprofloxacin | 1 (1) |
SD = standard deviation.
*
Except where indicated otherwise. The 69 patient cases represented a total of 68 patients; 1 patient had 2 separate courses of therapy that qualified for inclusion.