. Author manuscript; available in PMC: 2020 Jun 22.

Published in final edited form as: Respirology. 2017 Nov 7;23(1):18–27. doi: 10.1111/resp.13212

Table 1:

Replicated candidate gene association studies of OSA

Gene (publication)	Abbreviation	Chromosome	Year	Cases/controls	Findings:
Tumor necrosis factor-α⁴⁷	TNF-α	6	2014	1369/1064	TNF-α (−308G/A) polymorphism is a risk factor for OSA
Apolipoprotein E Epsilon 4⁴⁹	APOE ε4	19	2009	1901/4607	no causal relationship between the APOE ε4 locus and OSA
Prostaglandin E2 receptor EP3 subtype⁵⁰	PTGER3	1	2012	963/1965 European ancestry	rs1409986 SNP in the PTGER3 gene was significantly associated with OSA
Lysophosphatidic acid receptor 1⁵⁰	LPAR1	9	2012	233/414 African Americans	rs7030789 SNP in the LPAR1 gene was associated with OSA