Depressive symptoms, mental health-related quality of life, and survival among older patients with multiple myeloma

Abstract

Purpose

To examine the impact of pre-diagnosis depressive symptoms and mental health-related quality of life (HRQOL) on survival among older patients with multiple myeloma (MM).

Methods

We performed a retrospective cohort study using the Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey data resource. Patients aged 65 years and older diagnosed with first primary MM between 1998 and 2014 were identified and presence of depressive symptoms was determined based on responses to 3 depression screening questions prior to MM diagnosis. Veterans-RAND-12 mental component scores (MCS) were analyzed to evaluate mental HRQOL. We used multivariable Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for risks of all-cause and cancer-specific mortality.

Results

Of 522 patients, mean (SD) age at diagnosis was 76.9 (6.1) years and 158 (30%) reported depressive symptoms. Patients with depressive symptoms had a higher number of comorbid conditions and nearly all (84%) scored below the median MCS. Pre-diagnosis depressive symptoms were not associated with all-cause (HR=1.01, 95% CI: 0.79–1.29) or cancer-specific mortality (HR=0.94, 95% CI: 0.69–1.28). MM patients scoring in the second MCS tertile (versus the highest tertile) had a modestly increased risk of all-cause (HR=1.19, 95% CI 0.91–1.55) and cancer-specific mortality (HR=1.17, 95% CI 0.86–1.60), but these estimates were not statistically significant.

Conclusion

Pre-diagnosis depressive symptoms and lower mental HRQoL did not impact survival among older MM patients. Highly prevalent depressive symptoms among older MM patients deserves clinical attention. Such efforts can inform clinicians in tailoring care for this vulnerable population.

Introduction

Multiple myeloma (MM) is a plasma-cell malignancy characterized with proliferation of plasma cells in the bone marrow, monoclonal protein in the blood and urine, and end-organ dysfunction leading to significant morbidity and mortality [1, 2]. Although a rare disease, MM accounts for 17% of blood cancers making it the second most common hematological malignancy in the United States (US) [3]. MM is a cancer of older adults with median age at diagnosis of 70 years [1]. Survival of MM patients has improved in recent years due to treatment advancements including autologous stem cell transplantation and novel agents such as thalidomide, lenalidomide, and bortezomib [1], and 5-year survival rates for MM are slightly over 50% [3].

Depression among older adults is a major public health problem that is often underreported and underdiagnosed [4, 5]. Prevalence of depression is reported to be between 1% and 16% among patients 65 years and older [6]. High prevalence of depression in older patients often presents with several comorbidities, which together can worsen quality of life, increase healthcare utilization, and lead to higher risk for suicide [5]. Depression is also more common among cancer patients, approximately four-times higher than average depression rates in the general population [7].

Depression and poor mental health-related quality of life (HRQOL) can detrimentally impact cancer outcomes through the biobehavioral effects of psychological stressors [8]. Depression can potentially worsen cancer progression through compromised cancer defense mechanisms and dysregulated oxidative stress [8]. Depression and poor mental health are also associated with poor medication adherence, worse quality of life, longer hospitalizations, and suboptimal treatment outcomes among cancer patients [8–12].

Previous studies relating depression and poor mental HRQOL with cancer outcomes report inconsistent findings with a paucity of evidence among MM patients. Among studies evaluating depression and depressive symptoms in cancer patients, some indicated up to a two-fold greater risk of mortality [13–16], whereas others found no association [17]. Conflicting trends were also observed in studies relating poor mental HRQOL and survival among cancer patients [18–20]. Furthermore, previous studies were heterogeneous in terms of patient populations, cancer types, and depression definition, which can limit generalizability to MM patients. Lastly, the majority of studies assessed depression and mental HRQOL after cancer diagnosis and sometimes after treatment initiation [19]. These assessments can be influenced by subsequent cancer or treatment-related factors, which have been shown to impact depression and HRQOL [11, 21]. To our knowledge, no previous study evaluated the association between pre-diagnosis depressive symptoms or poor mental HRQOL and survival among patients with MM.

To fill this knowledge gap, we analyzed data from the Surveillance, Epidemiology, and End Results (SEER)-Medicare Health Outcomes Survey (MHOS). The SEER-MHOS data resource provides detailed clinical and HRQOL data for older Medicare beneficiaries in the US residing in regions covered by the SEER population-based cancer registries [22]. In addition, the SEER-MHOS data include specific questions regarding depression and mental HRQOL along with robust survival information of MM patients [22]. Our objective was to examine the impact of pre-diagnosis depressive symptoms and poor mental HRQOL on the survival of elderly MM patients.

Methods

Study design and population

We conducted a prospective cohort study utilizing the SEER-MHOS 1998 to 2014 data with information on vital status and cause of death through November 30^th, 2016. SEER-MHOS is a robust data resource that links information from two datasets (SEER and the MHOS surveys) to provide insights about older cancer patients in the US [22]. The SEER program of the National Cancer Institute collects information on cancer incidence and survival covering 99% of 18 population-based cancer registries that represent about 35% of the US population [23]. The SEER program has information on demographics, clinical characteristics (cancer diagnoses, extent of disease, tumor markers, surgery and radiation) and survival [24]. MHOS is a survey of patient reported outcomes from a randomly selected sample of Medicare Advantage plan beneficiaries [22]. MHOS baseline surveys are distributed yearly to over 140,000 Medicare Advantage enrollees with a follow-up survey collected every 2 years for patients still enrolled in the same plan [25]. Response rates for first and follow-up MHOS surveys are approximately 60% [25] and can be completed by the patient or by a proxy [22]. Information in MHOS includes self-reported demographics, socioeconomic status, comorbidities, functional status, and measures of HRQOL [22].

This study utilized data from SEER-MHOS cohorts between 1998 and 2014, composed of more than 140,000 cancer survivors [25]. Study population and inclusion/exclusion criteria are outlined in Figure 1. We included patients that were: (i) 65 years and older at time of SEER-MHOS survey; (ii) diagnosed with first primary MM between 1998 and 2014; and (iii) provided a minimum of one SEER-MHOS survey within 5 years prior to MM diagnosis. Among patients who completed multiple pre-diagnosis surveys, we examined the most recent survey prior to MM diagnosis. Patients were excluded if they were missing: all 3 depression screening questions, valid MM diagnosis date, and/or information on post-diagnosis survival months. Patients were also excluded if they took the survey or died in the same month of MM diagnosis. This study was determined to be exempt by the institutional review board of the University of Illinois at Chicago.

Figure 1:

Consort Diagram

Exposure Measures

Depressive symptoms and mental HRQOL were collected from SEER-MHOS surveys prior to MM diagnosis. Presence of pre-diagnosis depressive symptoms was based on results from Diagnostic Interview Schedule (DIS) 3-item questionnaire, administered at least 1 month prior to MM diagnosis. Presence of depressive symptoms was defined as affirmative response to one of the 3 following questions: (1) “In the past year, have you had 2 weeks of depression? (Yes/No);” (2) “In the past year, have you had depression much of the time? (Yes/No);” (3) “In the past 2 years, have you had depression most of the time? (Yes/No).” Previous studies defining depression in SEER-MHOS data used similar DIS criteria with one study including a mental component summary (MCS) threshold of <42 for characterizing depressive symptoms [26, 27]. While no information is available on the predictive performance of DIS in Medicare patients, a slightly different version of DIS demonstrated 83% to 94% sensitivity and above 90% specificity; [28] and a 2-item version of DIS studied in elderly patients with mean age of 53 years showed 96% sensitivity, 57% specificity, and area under the Receiver Operating Characteristic (ROC) curve of 0.82 [29]. Since there is no uniform definition for depressive symptoms in Medicare patients, sensitivity analyses were conducted to vary exposure over a plausible range and assess robustness of our findings. In one analysis, depressive symptoms definition was restricted to affirmative response to items 1 and 2 of DIS to improve recency of the exposure. Another sensitivity analysis was carried out by excluding proxy surveys.

Mental HRQOL was determined using the Mental Component Summary (MCS) score based on the Short Form Health Survey (SF-36) and Veterans Rand 12 Health Survey (VR-12). VR-12 is a patient-reported general health measure used to assess a patient’s overall perspective of their health [30]. VR-12 replaced SF-36 starting 2006 in SEER-MHOS data. Results from SF-36 and VR-12 were bridged using a published algorithm to account for missing data and make scores comparable across all SEER-MHOS cohorts [31]. Subscale scores for 8 physical and mental HRQOL domains were collected including physical functioning (PF), role limitation due to physical health problems (RP), bodily pain (BP), general health perception (GH), mental health (MH), role limitation due to personal or emotional problems (RE), social functioning (SF), and vitality or energy (VT). Group averages for HRQOL domains lie in 0 to 100 range [30]. Mental and physical component summary scores (MCS-12 and PCS-12) were computed based on subscale scores from mental and physical HRQOL domains. Higher MCS, PCS, and subscale scores signify better HRQOL [30].

Outcome Measures

The primary outcomes were cancer-specific and all-cause mortality using survival information documented by the SEER registries. Survival was defined as the proportion of MM patients alive subsequent to MM diagnosis as of November 30^th, 2016.

Statistical Analysis

Patient demographics, socioeconomic status, self-reported comorbidities, MM clinical characteristics, and survey characteristics were collected from SEER-MHOS survey prior to MM diagnosis. Demographic and socioeconomic data included age, race, sex, education, and marital status. Number of comorbidities was obtained by totaling responses to 15 self-reported comorbidity questions. Possible comorbidities included the following: heart conditions (hypertension, angina or coronary artery disease, congestive heart failure, acute myocardial infarction, other heart conditions), stroke, pulmonary conditions (emphysema, asthma, COPD), Crohn’s Disease, Ulcerative Colitis, Inflammatory Bowel Disease, diabetes, arthritis, and sciatica. If a patient was missing data on any comorbidity, then number of comorbid conditions was considered missing. Number of heart, pulmonary and cardiovascular conditions were computed as appropriate with aggregates deemed missing if responses to any of the individual comorbid conditions were missing. Survey characteristics encompassed number of months from MHOS survey to MM diagnosis, survey disposition (mail/telephone), and survey respondent (patient/proxy).

Self-reported general health, MCS-12, PCS-12, and HRQOL domains were also described. Bivariate analyses were conducted to compare demographics, clinical characteristics, and HRQOL measures for patients with and without pre-diagnosis depressive symptoms. Chi square and Fisher tests were used for categorical data and Wilcoxon rank sum test for continuous data with a 0.05 significance level.

Cox proportional hazards models were used to estimate crude and adjusted HR and 95% CI for the association between each of pre-diagnosis depressive symptoms and mental HRQOL with risks of all-cause and cancer-specific mortality. Estimates from Cox models were adjusted for sex, race, age, education, categories of number of comorbidities, marital status, PCS score (tertiles), year of diagnosis, and smoking status. Competing risks were accounted for in models for cancer-specific mortality by estimating cause-specific hazards and censoring at the time of other-cause death [32]. All-cause mortality estimates were calculated in the absence of competing risks. Possible interaction between depressive symptoms and mental component scores were evaluated in sensitivity analyses including interaction terms and stratification. The proportional hazards assumption was evaluated using interaction of log-follow up time and graphical assessments based on scaled Schoenfeld residuals. No evidence was observed to suggest violation of the proportionality assumption. All analysis was performed in SAS version 9.4 (Cary, NC).

Results

Demographics and clinical characteristics are reported in Table 1. Of the 522 patients diagnosed with first primary MM between 1998 and 2014 and included in the final analytic sample, 158 (30%) reported depressive symptoms prior to MM diagnosis. Patients had a mean (SD) age of 77 (6) years, with most patients (59%) at age 75 years or older. Sixty percent of patients identified as white and 18% were black. Overall, patients reported an average of 2.7 comorbid conditions with 74% reporting at least 1 heart condition.

Table 1:

Demographics and clinical characteristics

Characteristics	Total (n=522)		Depressive Symptoms (n=158)		No Depressive Symptoms (n=364)		P
	n	%	n	%	n	%
Age at diagnosis Mean, (SD)	76.9	6.1	76.0	6.6	75.1	6.0	0.13
65 – 74	215	41.2%	61	38.6%	154	42.3%
75 – 84	244	46.7%	71	44.9%	173	47.5%
85+	63	12.1%	26	16.5%	37	10.2%
Race/ Ethnicity							0.35
White	312	59.8%	87	55.1%	225	61.8%
Black or African American	95	18.2%	32	20.3%	63	17.3%
Other	115	22.0%	39	24.7%	76	20.9%
Sex							0.02
Male	259	49.6%	66	41.8%	193	53.0%
Female	263	50.4%	92	58.2%	171	47.0%
Marital status							<0.01
Married	287	55.0%	68	43.0%	219	60.2%
Not married	225	43.1%	86	54.4%	139	38.2%
Education							<0.01
Less than high school	161	30.8%	70	44.3%	91	25.0%
High school graduate or GED	157	30.1%	48	30.4%	109	29.9%
College or above	190	36.4%	34	21.5%	156	42.9%
Smoking status							<0.01
Yes (every day or some days)	49	9.4%	27	17.1%	22	6.0%
Not at all	399	76.4%	111	70.3%	288	79.1%
Unknown	74	14.2%	20	12.7%	54	14.8%
Number of comorbid conditionsa Mean, (SD)	2.7	2.0	3.5	2.1	2.4	1.8	<0.01
0–2	248	47.5%	56	35.4%	192	52.7%
3 or more	214	41.0%	80	50.6%	134	36.8%
Heart conditionsb							0.03
At least 1 heart condition	384	73.6%	126	79.7%	258	70.9%
No heart conditions	137	26.2%	31	19.6%	106	29.1%
Stroke
Yes	48	9.2%	19	12.0%	29	8.0%	0.13
No	464	88.9%	135	85.4%	329	90.4%
Cardiovascular conditionsc							0.01
At least 1 cardiovascular condition	387	74.1%	128	81.0%	259	71.2%
No cardiovascular conditions	133	25.5%	29	18.4%	104	28.6%
Diabetes							0.03
Yes	123	23.6%	47	29.7%	76	20.9%
No	392	75.1%	109	69.0%	283	77.7%
Arthritis							<0.01
Arthritis	290	55.6%	107	67.7%	183	50.3%
No arthritis	229	43.9%	49	31.0%	180	49.5%
Asthma/COPD/Emphysema							<0.01
Yes	73	14.0%	34	21.5%	39	10.7%
No	441	84.5%	121	76.6%	320	87.9%
Sciatica							<0.01
Yes	116	22.2%	51	32.3%	65	17.9%
No	397	76.1%	104	65.8%	293	80.5%
Year of Multiple Myeloma Diagnosis							0.02
1998–2005	207	39.7%	66	41.8%	141	38.7%
2006–2010	155	29.7%	34	21.5%	121	33.2%
2011–2013	160	30.7%	58	36.7%	102	28.0%
Number of months from survey to diagnosis Mean, (SD)	23.1	18.1	22.2	16.8	23.6	18.7	0.42
MHOS survey disposition							0.54
Mail	450	86.2%	134	84.8%	316	86.8%
Telephone	72	13.8%	24	15.2%	48	13.2%
Who completed survey							0.01
Patient	416	79.7%	112	70.9%	304	83.5%
Proxy	70	13.4%	30	19.0%	40	11.0%

^a:Possible patient reported comorbidities include hypertension, angina or coronary artery disease, congestive heart failure, acute myocardial infarction, other heart conditions, stroke, pulmonary conditions (emphysema, asthma, COPD), Crohn’s Disease, Ulcerative Colitis, or Inflammatory Bowel Disease, diabetes, arthritis, sciatica. If patient is missing data on any comorbidity, then number of comorbid conditions is considered missing

^b:Possible patient reported heart conditions include hypertension, angina or coronary artery disease, congestive heart failure, acute myocardial infarction, other heart conditions

^c:Include heart conditions and stroke

Note: Column percentages do not sum to 100% for some variables due to missing data

Fewer patients with pre-diagnosis depressive symptoms were married (43% vs 60%, P<0.01) and reported lower rates of college level education or above (22% vs 43%, P<0.01) compared to patients without depressive symptoms. Mean (SD) number of self-reported comorbidities was 3.5 (2.1) in patients with depressive symptoms compared to 2.4 (1.8) comorbidities in the comparator group (P<0.01). Surveys were mostly completed by patients (80%) and administered at average of 23 months prior to MM diagnosis; and survey responses were completed by proxy at higher rates among patients with depressive symptoms compared to those without depressive symptoms (P<0.01).

Results from general health, mental and physical HRQOL measures are described in Table 2. For HRQOL measures, the proportion of patients with depressive symptoms reporting poor or fair general health was more than double (52% vs 23%, P<0.01). Nearly all (84%) of patients with depressive symptoms scored below the median MCS-12 score, compared to 35% of the comparator group (P<0.01). Similar trends were observed in PCS-12 and HRQOL domain scores with significantly lower scores among patients with depressive symptoms. HRQOL domains differed between groups with and without depressive symptoms by 20 points or higher on average for PF, RP, MH, and RE (P<0.01).

Table 2:

General, mental and physical health-related quality of life

Characteristics	Total (n=522)		Depressive Symptoms (n=158)		No Depressive Symptoms (n=364)		P
	n	%	n	%	n	%
General Health
Poor or Fair	164	31.4%	82	51.9%	82	22.5%	<0.01
Good or above	349	66.9%	69	43.7%	280	76.9%
MCS-12 Median, (IQR)	53.8	43.3–59.3	39.7	33.7–48.6	56.9	51.2–60.7	<0.01
MCS-12 Categories
Below or equal to median	260	50.1%	133	84.7%	127	35.1%	<0.01
Above median	259	49.9%	24	15.3%	235	64.9%
PCS-12 Median, (IQR)	38.8	29.5–48.8	32.7	24.3–41.7	41.4	31.8–50.9	<0.01
PCS-12 Categories
Below or equal to median	261	50.0%	106	67.1%	155	42.6%	<0.01
Above median	261	50.0%	52	32.9%	209	57.4%
HRQL Domains
PF Median, (IQR)	58.3	36.6–90.0	49.5	17.5–70.0	71.4	45.0–93.5	<0.01
RP Median, (IQR)	50.0	0.5–100.0	9.8	0.0–53.0	75.0	9.8–100.0	<0.01
BP Median, (IQR)	56.3	39.0–84.0	41.0	31.3–54.1	56.3	44.0–95.2	<0.01
GH Median, (IQR)	61.5	40.0–77.0	46.0	37.5–61.5	61.5	52.0–82.0	<0.01
MH Median, (IQR)	83.7	60.7–92.0	56.0	44.0–69.5	84.0	76.0–92.7	<0.01
RE Median, (IQR)	100.0	33.3–104.1	33.3	0.0–75.1	100.0	66.7–104.1	<0.01
SF Median, (IQR)	87.5	50.0–99.3	50.0	37.5–75.0	99.3	66.9–100.0	<0.01
VT Median, (IQR)	54.6	40.0–79.3	40.9	30.0–50.0	59.7	45.9–79.3	<0.01

IQR: Interquartile Range; PCS-12: Physical Component Summary score; MCS-12: Mental Component Summary score; VR-12: Veteran Rand 12-item questionnaire; HRQoL: Health-related Quality of Life; PF: Physical Functioning, RP: Role limitation due to physical health problems, BP: Bodily pain, GH: General health perception, MH: Mental health, RE: Role limitation due to personal or emotional problems, SF: Social functioning, VT: Vitality or energy

Results from Cox proportional hazards models for associations of pre-diagnosis depressive symptoms and MCS-12 with all-cause and cancer-specific mortality risks are reported in Table 3 and Table 4, respectively. Pre-diagnosis depressive symptoms were not associated with all-cause (HR 1.01, 95% CI: 0.79–1.29) or cancer-specific mortality (HR 0.94, 95% CI: 0.69–1.28). Myeloma patients scoring in the second MCS tertile (versus the highest tertile) showed a trend toward higher risk of all-cause (HR 1.19, 95% CI 0.91–1.55) and cancer-specific mortality (HR 1.17, 95% CI 0.86–1.60). However, these estimates were not statistically significant. No significant associations were observed when comparing the first MCS tertile to the third tertile in terms of all-cause (HR 1.07, 95% CI 0.80–1.43) and cancer-specific mortality (HR 0.98, 95% CI 0.68–1.40). Sensitivity analyses of 2-item DIS and proxy survey exclusion did not show substantively different results with respect to direction or statistical significance (Table S2). In sensitivity analyses stratifying the effects depressive symptoms and MCS tertiles on all-cause and cancer-specific mortality, there was no evidence suggesting significant interaction between pre-diagnosis depressive symptoms and MCS-12 (Tables S3 and S4).

Table 3:

All-cause and cancer-specific mortality for patients with depressive symptoms prior to multiple myeloma diagnosis

All-Cause Mortality (total survival time=15,279 months, Events=363)
Covariate	Person Years	Events	Crude Model (n=522)			Minimally Adjusteda (n=522)			Fully Adjustedb (n= 506, Events=354c)
			HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
No depressive symptoms (reference)	903.33	254	1	-	-	1	-	-	1	-	-
Depressive symptoms	369.92	109	1.04	0.83–1.30	0.74	1.04	0.82–1.30	0.76	1.01	0.79–1.29	0.94
Cancer Specific Mortality (total survival time=15,279 months, Events=247)
Covariate	Person Years	Events	Crude Model (n=522)			Minimally Adjusteda (n=522)			Fully Adjustedb (n=506, Events=241c)
			HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
No depressive symptoms (reference)	903.33	180	1	-	-	1	-	-	1	-	-
Depressive symptoms	369.92	67	0.90	0.68–1.20	0.48	0.90	0.67–1.19	0.45	0.94	0.69–1.28	0.70

^a:adjusted for age, sex, race

^b:adjusted for sex, race, age, education, categories of number of comorbidities, marital status, PCS score (tertiles), year of diagnosis, smoking status

^c:Number of events for fully adjusted model was lower than crude and minimally adjusted models due to missing values in covariates included for adjustment.

Table 4:

All-cause and cancer-specific mortality for patients with poor mental health prior to multiple myeloma diagnosis

All-Cause Mortality (total survival time=15,244 months, Events=360)
Covariate	Person years	Events	Crude Model (n=519)			Minimally Adjusteda (n=519)			Fully Adjustedb (n=503, Events=351c)
			HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
MCS-12
Third tertile (reference)	437.92	117	1	-	-	1	-	-	1	-	-
Second tertile	423.58	122	1.08	0.84–1.39	0.56	1.12	0.87–1.45	0.39	1.19	0.91–1.55	0.20
First tertile	408.83	121	1.10	0.85–1.42	0.47	1.12	0.87–1.45	0.38	1.07	0.80–1.43	0.65
Cancer Specific Mortality (total survival time =15,244 months, events = 244)
Covariate	Person years	Events	Crude Model (n=519)			Minimally Adjusteda (n=519)			Fully Adjustedb (n=503, Events=238c)
			HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
MCS-12
Third tertile (reference)	437.92	84	1	-	-	1	-	-	1	-	-
Second tertile	423.58	87	1.07	0.79–1.45	0.66	1.10	0.81–1.48	0.55	1.17	0.86–1.60	0.32
First tertile	408.83	73	0.92	0.67–1.26	0.67	0.93	0.68–1.28	0.65	0.98	0.68–1.40	0.89

^a:adjusted for age, sex, race

^b:adjusted for sex, race, age, education, categories of number of comorbidities, marital status, PCS score (tertiles), year of diagnosis, smoking status

^c:Number of events for fully adjusted model was lower than crude and minimally adjusted models due to missing values in covariates included for adjustment

MCS-12: Mental Component Summary score

Discussion

To our knowledge, this is the first study assessing the impact of pre-existing depressive symptoms and poor mental HRQOL on the survival of MM patients. We found a high prevalence of pre-diagnosis depressive symptoms in older patients prior to diagnosis with first primary MM. Patients with depressive symptoms reported a higher number of comorbidities and lower scores indicating worse general, mental and physical HRQOL compared to patients without depressive symptoms. We found no significant associations between pre-diagnosis depressive symptoms and poor mental HRQOL with all-cause or cancer-specific survival among older MM patients included in our study. Although not directly impacting survival, the high burden of depressive symptoms and poor mental health status among older patients with MM deserves clinical attention.

Depression and depressive symptoms may impact patients’ cancer treatment choices and could also lead to suboptimal treatment outcomes [9, 10]. The association between depression and cancer outcomes can be elucidated through the biobehavioral model for cancer progression [8, 7]. In brief, it is hypothesized that psychosocial stressors (i.e., depression) lead to higher resistance to cell death, compromised immunity, dysregulation of the autonomic nervous system, and inflammatory and oxidative stress, which in turn have detrimental effects on cancer progression [8]. Furthermore, depression is associated with longer hospitalizations, worse quality of life, poor medication adherence, and greater risk of suicide among cancer patients [8]. Among women with breast cancer, depression and use of antidepressants are also associated with non-adherence to adjuvant endocrine therapy [11, 12]. In the context of hematological cancers, pre-transplant depression is associated with lower all-cause survival and higher risk for acute graft rejection among allogenic stem-cell transplant recipients [10].

To our knowledge, all studies assessing depressive symptoms and poor mental HRQOL among MM patients were based on post-diagnosis surveys. A study of 305 MM patients with median age of 76 years reported poorer all-cause survival in patients with higher post-diagnosis frailty, which included components of mental and physical health among other factors[33]. Another study of 3019 MM patients with mean age of 69 years found no difference in MCS between newly diagnosed MM patients and patients with no history of cancer[34].

As for other cancers, very few studies evaluated the impact of pre-diagnosis depressive symptoms and mental HRQOL. In one study of postmenopausal breast cancer patients (ages 50 to 79 years), a 35% higher risk of all-cause mortality among patients with depression defined by the presence of pre-diagnosis depressive symptoms or use of antidepressants prior to cancer diagnosis (HR 1.35, 95% CI: 1.02–1.78) [13]. This association with pre-diagnosis depressive symptoms was found to be even greater in women who with late-stage breast cancer for both risks of all-cause (HR 2.00, 95% CI: 1.13–3.56) and cancer-specific death (HR 2.42, 95% CI: 1.24–4.70). In our study we identified depressive symptoms based on a positive DIS screen. It is possible that the null association with mortality risk was observed due to differences in defining our exposure. In one study of 6290 lung cancer patients ages 65 year and older using the SEER-MHOS data resource [20], a 4% lower risk for all-cause death was reported with five-point increase in MCS (HR 0.96, 95% CI: 0.95–0.98). A similar trend indicating an inverse association between higher mental HRQOL and mortality in patients with cancer was observed with a 24% decreased hazards of death among patients that scored above MCS population average (MCS 50 or higher). Another SEER-MHOS study of older patients with lung cancer found no significant association between MCS and overall survival (5 point HR 1.05, 95% CI: 0.98–1.11) [19]. While both studies included older patients with characteristics fairly similar to our cohort, the latter study differed in its requiring patients to have responded to a survey both prior to and following cancer diagnosis.

This analysis has strengths, especially the extensive and robust population-based information included in SEER-MHOS data. We were able to account for important factors such as patient demographics and comorbidities than can impact depressive symptoms, mental HRQOL, and survival. Furthermore, the majority of previous studies assessed depressive symptoms and HRQOL after cancer diagnosis; and to our knowledge, this is the first study evaluating the impact of pre-diagnosis depressive symptoms and poor mental HRQOL on cancer outcomes among MM survivors.

Our study also has several limitations. Common to survey-based observational studies, variable response by certain patient characteristics and inability to draw causal inference are possible limitations. Consistent with previous studies, we addressed variable survey response by adjusting for several demographic and clinical patient characteristics [34]. While the SEER registries cover approximately 35% of the U.S. population, certain regions such as states of Florida and Minnesota are not represented [22]. At the same time, SEER data are limited by a lack of information on some cancer treatments documented in the registries. Further, Medicare Advantage enrollees may differ systematically from others, such as Medicare fee-for-service beneficiaries; however, studies indicate conflicting results [35, 36]. Results from this study are not necessarily generalizable to patients younger than 65 years and residual confounding by unmeasured covariates is possible. We lacked information on other important clinical information including type and duration of treatment, receipt of bone marrow transplantation, disease recurrence and progression, severity of depression, and whether or not patients were receiving depression treatment. Our study characterized depressive symptoms assessed up to 5 years prior to cancer diagnosis. Consistent with other studies, longer time between depression screening and cancer diagnosis may attenuate a possible association with cancer survival if one exists [13].

Our null findings could be explained by several factors. Our study may have been underpowered to differentiate differences by subgroups of recency. Also, protective factors such as resilience and posttraumatic growth have been linked to favorable psychological and treatment-related outcomes among cancer survivors [37]. As a result, those factors can ameliorate the impact of pre-diagnosis depressive symptoms and poor mental health on mortality.

As advances in the treatment of MM lead to greater survival years, additional research and efforts to alleviate the psychosocial burdens associated with cancer are equally necessary. Older patients have higher risk for social isolation, which can be detrimental to their wellbeing [38]. Furthermore, the diagnosis of cancer and aggressive cancer treatment can further exacerbate the burdens of depression and poor mental health in this populations [11, 21]. After cancer treatment, psychosocial problems such as depression can hinder the ability of cancer survivors to successfully return to their work and social life [39]. Our findings highlight the high prevalence of pre-existing depressive symptoms and poor mental HRQOL among older patients diagnosed with MM. Larger studies of both younger and older MM patients treated in the novel agent era may help inform the evidence base for universal depression and HRQOL screening in the regular care of MM.

Conclusion

Depressive symptoms and mental HRQOL assessed prior to cancer diagnosis did not significantly impact survival of older patients with multiple myeloma. Additional research is essential to understand the high prevalence of pre-diagnosis depressive symptoms and poor mental HRQOL and explore their impact on future risks of major depressive disorder, treatment acceptability and clinical decision making following MM diagnosis. Lastly, prospective studies and clinical trials should determine whether life-prolonging novel therapies also improve mental HRQOL.