Fig. 1. Figure showing thiopurine metabolism. 6-MMP: 6-methylmercaptopurine, 6-MP: 6-mercaptopurine, 6-TU: 6-thiouric acid, TPMT: thiopurine S-methyltransferase, XO: xanthine oxidase, HPRT: hypoxanthine phosphoribosytransferase, 6-MMPR: 6-methylmercaptopurine riboside, 6-TIMP: 6-thioinosine 5′-monophosphate, IMPDH: inosine 5′-monophosphate dehydrogenase, 6-TXMP: 6-thioxanthylic acid, GMPS: guanosine 5′-monophosphate synthetase, 6-TGN: 6-thioguanine nucleotides.
