Fig. 1.
LXR agonists acutely inhibit stimulus-secretion coupling in wild type β-cells. a Representative recording of Vm with administration of T0901317 (T09). b Summary of all experiments. n = 16. c Representative recording of Vm with administration of GW3965 (GW). Tolbutamide (Tb) was given at the end of the experiment to test whether closure of KATP channels is still possible. d Summary of all experiments. n = 7. e Glucose-induced insulin secretion is reduced by T0901317 compared with control islets in the presence of 15 mM glucose (G15). n = 6. f GW3965 also decreased glucose-induced insulin secretion. n = 8. Experiments were performed with different islet cell clusters or islets from 3–7 mice. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001