Table 2.
Summary of the time constant determined for 2.5 μM GABA with and without preincubation with 018 and calculated percentage contribution of the fast-rising current (%A1) relative to the total induced current.
| 018 (nM) | τ1 (ms) | τ2 (ms) | %A1 | n |
|---|---|---|---|---|
| 0 | 174 [148;186]a | — | — | 6 |
| 0.1 | 119 [101;167]a | — | — | 10 |
| 3 |
147 [115;183] 123 [73.3;273]a |
1090 [960;2180] — |
83.8 — |
7 3 |
| 10 | 107 [57.5;180] | 2170 [1970;3010] | 39.6 | 5 |
| 30 |
68.0 [56.3;106] — |
3780 [3160;4710] 4270 [4140;4920]a |
8.3 — |
5 3 |
| 1000 | — | 3780 [3330;5350]a | — | 5 |
If not otherwise stated, current traces were best fitted using a biexponential function. Data are given as medians followed by 25–75% quartiles in squared brackets. n denotes the number of tested cells. Statistics are shown and described in Fig. 4B. aCurrent traces were best fitted using a monoexponential function.