Table 3.
Association between urine 6-bromotryptophan and incident ESKD.
| Categorya: | Cause-specific hazard ratio (95% confidence interval) | ||
|---|---|---|---|
| Undetectable | Low | High | |
| Model 1 | 1.00 | 0.63 (0.46, 0.86) | 0.39 (0.27, 0.57) |
| Model 2 | 1.00 | 0.59 (0.43, 0.81) | 0.33 (0.23, 0.49) |
| Model 3 | 1.00 | 0.64 (0.46, 0.88) | 0.39 (0.26, 0.58) |
| Model 4 | 1.00 | 0.70 (0.51, 0.97) | 0.50 (0.34, 0.74) |
| Model 5 | 1.00 | 0.98 (0.71, 1.36) | 1.25 (0.83, 1.89) |
N = 4,843, Nevents = 216.
aSubcategories according to levels of urine 6-bromotryptophan: undetectable levels; low: range: 0.135 to <0.84 (median); high: range: 0.84 (median) to 5.31.
Covariate adjustment:
Model 1: unadjusted.
Model 2: age + sex.
Model 3: Model 2 + smoking + waist-to-hip ratio + diastolic blood pressure + prevalent diabetes + coronary heart disease + high density lipoprotein cholesterol + low density lipoprotein cholesterol + diuretic use.
Model 4: Model 3 + urine albumin-to-creatinine ratio.
Model 5: Model 4 + eGFR.