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. 2020 Jun 22;11:3162. doi: 10.1038/s41467-020-16966-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The volcano plot of the identified proteins. The proteins significantly enriched in the tobramycin purified samples are shown as red dots. Log₂ fold change was plotted on the x-axis and −log₁₀ P value was plotted on the y-axis. b The protein interactome network of HULC. PPI information was obtained through a database search using String 9.0 and imported into Cytoscape 3.1.1 for network construction. Proteins and their interactions are shown as nodes and edges. Node size reflects the interaction degree. Proteins are grouped based on their known biological functions. c Validation of selected identified proteins by RIP. Immunoblots of TGM2, DDX58, LGALS3BP, H2A and PDIA3 in the cell lysates and immunoprecipitates are shown in the upper panel. The agarose gel electrophoresis images of HULC amplified by qRT-PCR are shown in the lower panel. LincRNA-p21 was used as an irrelevant lncRNA control. See also Supplementary Figs. 2 and 3. Source data are provided as a Source Data file.