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. 2020 Jun 22;10:10060. doi: 10.1038/s41598-020-66964-0

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MAIT cells drive B cells toward tissue resident memory B cell formation. (A,B) The fold change (calculated based on respective B cell alone data) of CD21⁻CD27⁻ TLM B cells of naïve B cells stimulated with enriched (A) or sorted (B) MAIT cell supernatants in vitro. (C–J) Association or trend of association of the frequency of MAIT cells in blood or BAL 7 dpv with SIV Env-specific memory B cells in rectal mucosa 21 dpv. Data of (A,B) were analyzed by the Wilcoxon paired test. Horizontal and vertical bars denote mean and SEM. *p < 0.05. Data of (C–J) were analyzed by the Spearman correlation test.