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. 2020 Jun 22;10:10065. doi: 10.1038/s41598-020-66786-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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db/db mice lacking miR-204 have better blood pressure decline during inactivity. (a) The representative curve of 24 hr (day and night) telemetric recording of the average mean arterial pressure (MAP) in the wildtype, db/+−204^−/−, db/db, and db/db-204^−/− mice. Wildtype: n = 3, db/+−204^−/−: n = 7, db/db: n = 7, and db/db-204^−/−: n = 6. (b) The mouse locomotor activity distribution in quartiles. The ‘y’ axis shows an hourly mean activity quartile. 1; 0–25%, ≥2; 25–100%. The ‘x’ axis shows time (24 h) beginning at 6:00 PM. (c–e) The MAP during activity quartile ≥2 (c), activity quartile 1 (d) and a difference in the MAP during activity quartile ≥2 and activity quartile 1 (e). Wildtype: n = 3, db/+−204^−/−: n = 7, db/db: n = 7, db/db-204^−/−: n = 6. *p < 0.05; **p < 0.01; ***p < 0.001 vs. indicated group. In box-and-whisker plots, whiskers show minima and maxima and the central line indicates median. The significance of the difference between groups was performed by one-way analysis of variance (ANOVA) followed by Tukey’s test.