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. 2020 Jun 22;11:3161. doi: 10.1038/s41467-020-16489-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Juxta-cellular recordings of anaesthetized ≤P13 pups with odor and vocalization stimuli. b Responses to sibling and non-sibling odor (top), raster (middle), and peristimulus time histogram (bottom). Colored lines: timing of odors. c Firing rates for baseline (left), odor (middle), and offset (right). Data represent the mean (thick line) ± s.e.m. (shaded area). Sibling odor (n = 15 trials; mean ± s.e.m.; baseline = 0.13 ± 0.10 Hz, odor = 1.09 ± 0.22 Hz, difference = 0.96 ± 0.21; p = 4.0e−4, paired t-test) and non-sibling odor (n = 16 trials; mean ± s.e.m.; baseline = 0.59 ± 0.27 Hz; odor = 0.73 ± 0.21 Hz; difference = 0.13 ± 0.34; p = 0.705, paired t-test). d Conventions as in b. e Conventions as in c. Mother odor (n = 15 trials; baseline median = 0.00 Hz; odor median = 2.00 Hz; p = 3.7e−4, Wilcoxon signed rank test) and non-mother odor (n = 16 trials; mean ± s.e.m.; baseline = 0.25 ± 0.11 Hz; odor = 1.40 ± 0.24 Hz; difference = 1.15 ± 0.19; p = 2.2e−5, paired t-test). f Percent responsive neurons for each stimulus. Responsive neuron: significant change in firing rate within stimulus relative to baseline. Significance analyzed when trials ≥ 3. Left: Percent neurons responsive for each stimulus (n = responsive/total; sibling odor: n = 8/34, non-sibling odor: n = 5/35, fruit odor: n = 0/9, mother odor: n = 5/36, non-mother odor: n = 4/34, sibling call: n = 2/25, non-sibling call: n = 3/25). Right: Percent neurons inhibited or excited (n = inh:exc; sibling odor (s): n = 1:7; non-sibling odor (ns): n = 1:4; fruit (f): n = 0:0; mother odor (m): n = 2:3; non-mother odor (nm): n = 2:2; sibling call (sc): n = 2:0; non-sibling call (nsc): n = 2:1). g Of responsive neurons: 60.0% (9 neurons) responded to one stimulus and 40.0% (6 neurons) responded to multiple stimuli (top). 73.33% (11 neurons) responded to odors only, 13.33% (2 neurons) responded to only calls, and 13.33% (2 neurons) responded to calls and odors (bottom). All tests are two-tailed. For detailed statistical information, see Supplementary Table 1. ***p < 0.001.