Table 1.
Demographics and Immunosuppression Regimens of Transplant Recipients in the Influenza Infection and Vaccine Cohorts.
| Influenza infection (n = 31) | Influenza vaccine (n = 25) | p-value | |
|---|---|---|---|
| Demographics | |||
| Age, y, median (IQR) | 54.8 (39.0–63.9) | 59.0 (49.5–62.5) | 0.239 |
| Male sex | 19 (61.3) | 22 (88.0) | 0.034 |
| Time after transplant, y, median (IQR) | 2.4 (0.2–4.9) | 3.5 (1.0–7.5) | 0.259 |
| Type of transplant | |||
| Kidney | 13 (41.9) | 6 (24.0) | 0.001 |
| Liver | 0 (0) | 5 (20.0) | |
| Lung | 16 (51.6) | 5 (20.0) | |
| Heart | 2 (6.5) | 4 (16.0) | |
| Combined | 0 (0) | 5 (20.0) | |
| Immunosuppression | |||
| ATG in the last 3 months | 4 (12.9) | 1 (4.0) | 0.367 |
| Prednisone | 31 (100) | 19 (76.0) | 0.005 |
| daily dose (mg), median (IQR) | 15.0 (7.5–20.0) | 5.0 (1.3–5.0) | <0.001 |
| Calcineurin inhibitor | 31 (100) | 31 (100) | — |
| Tacrolimus | 16 (51.6) | 16 (64.0) | 0.352 |
| trough (µg/l), median (IQR) | 8.1 (5.9–12.5) | 6.8 (4.4–8.9) | 0.251 |
| Cyclosporine | 15 (48.4) | 9 (36.0) | 0.352 |
| trough (µg/l), median (IQR) | 206 (163–256) | 145 (102–271) | 0.283 |
| Sirolimus | 0 (0) | 1 (4.0) | 0.446 |
| MMF | 19 (61.3) | 18 (72.0) | 0.4 |
| daily dose (mg), median (IQR) | 1440 (720–1440) | 1040 (720–1440) | 0.169 |
| Azathioprine | 1 (3.2) | 3 (12.0) | 0.314 |
IQR: interquartile range; ATG: antithymocyte globulin; MMF: mycophenolate mofetil.