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. 2020 Jan 30;27(7):2248–2262. doi: 10.1038/s41418-020-0500-9

Fig. 8. Both mTORC1 and mTORC2 signals in γδ T cells are pathogenic in a psoriasis-like mouse model.

Fig. 8

a, b WT, Raptor KO, and Rictor KO mice were induced psoriasis with IMQ method. At day 7 post induction, mice were sacrificed with pictures shown. c PASI score was analyzed for 5–6 mice in each group. d H&E staining for the inflamed skin was shown. e, f WT, Raptor KO and Rictor KO mice were sacrificed and dermal CD45+ cells were analyzed for γδ TCR and IL-17 staining. Each symbol represents an individual mouse. Statistics of 5 mice for each group was shown in (e). Representative plots were shown in (f). g, h Dermal γδ T cells were gated and analyzed for IFN-γ and IL-17 expression. Each symbol represents an individual mouse. Statistics of 5 mice for each group was shown in (g) and representative plots were shown in (h). Data are means ± SEM. ns, not significant; *P < 0.05, **P < 0.01 and ***P < 0.001 (two-tailed unpaired t test). Data are representative of two independent experiments. Numbers indicate percentage of cells in quadrants.