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. 2020 Jan 20;27(7):2191–2205. doi: 10.1038/s41418-020-0494-3

Fig. 3. LINC00662 promotes oncological behaviors in vivo.

Fig. 3

a Schematic representation of xenografts based on two different models in vivo. b Representative images of the mice (upper panel) and removed tumors (lower panel) formed in nude mice that were subcutaneously injected with cells stably transfected with LINC00662-shRNA or empty vector. c The effects of LINC00662 on tumor growth are summarized by a tumor growth curve (left panel) and tumor weight graph (right panel). Error bars represent the SD (n = 5). d Microscopic images of HE and immunohistochemical staining patterns for Ki-67 in tumor xenografts from the nude mice in the LINC00662 knockdown group and the control group (scale bars = 24 μm). e Representative images of visible metastatic nodules in the mouse lungs (left panel) and HE staining of metastatic nodules in the lungs (right panel). The black arrows indicate tumors. f Quantitative comparison of metastatic nodules between the scramble group and LINC00662-shRNA group. *P < 0.05, **P < 0.01, ***P < 0.001.