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. 2020 Jun 22;11:3155. doi: 10.1038/s41467-020-16904-3

Fig. 3. ROGUE enhances single-cell clustering and cell-type identification.

Fig. 3

a t-SNE plots of a simulated dataset containing three cell types. Corresponding silhouette values (b) and average ROGUE values (c) when there were 2, 3, 4, and 5 putative clusters, respectively. d UMAP plots of lung-cancer-associated fibroblasts, color-coded by clusters in original paper (left; Supplementary Fig. 17a) and re-clustered labels (right). e ROGUE values of different clusters before (left) and after (right) re-clustering. Each point represents a patient. The center line indicates the median ROUGE value. The lower and upper hinges represent the 25th and 75th percentiles respectively, and whiskers denote 1.5 times the interquartile range. f UMAP plot of expression levels of MYH11 and MEF2C. g Differences in hallmark pathway activities scored using GSVA.