Table 6.

Logistic regression analysis of acute toxicities adjusted to prolonged exposure to methotrexate, drug dose, age, and genotype.

Polymorphism	Genotype	Hepatotoxicity	P value	Vomiting	P value
80 G>A SLC19A1	hom GG het GA hom AA	1.00 (–) 1.44 (0.81–2.55) 1.87 (0.96–3.63)	– NS 0.066	1.00 (–) 0.40 (0.16–1.02) 0.85 (0.35–2.03)	– 0.054 NS
2R>3R TS	hom 2R/2R het 2R/3R hom 3R/3R	1.00 (–) 1.46 (0.78–2.73) 2.28 (1.05–4.95)	– NS 0.038	1.00 (–) 3.20 (1.33–7.68) 3.39 (1.12–10.23)	– 0.009 0.031
677 C>T MTHFR	hom CC het CT hom TT	1.00 (–) 1.07 (0.63–1.81) 1.22 (0.65–2.29)	– NS NS	1.00 (–) 0.83 (0.43–1.63) 1.34 (0.32–5.59)	– NS NS

Data are shown as odds ratios with 95% confidence intervals.

NS, non significant.