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. 2020 Jun 16;11:1220. doi: 10.3389/fmicb.2020.01220

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Copyright © 2020 Tió-Coma, Avanzi, Verhard, Pierneef, van Hooij, Benjak, Roy, Khatun, Alam, Corstjens, Cole, Richardus and Geluk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Study design, RLEP positivity and genotyped samples. Flow diagram providing an overview of the subjects recruited for this study. Slit skin smears (SSS) and nasal swabs (NS) collected per group; healthy household contacts (HHC), paucibacillary (PB) or multibacillary (MB) patients with BI 0, and MB patients with a bacteriological index (BI) 2–6. MB patients with BI 1 were not diagnosed within the course of this study. DNA was isolated from SSS and NS and screened for M. leprae DNA by RLEP PCR. Samples were genotyped by Sanger sequencing (Monot et al., 2009; Truman et al., 2011) or Whole Genome Sequencing (Benjak et al., 2018). Percentages of the samples positive for RLEP PCR and genotyped are shown.