Table 1.

Summary of three reported cases of skull metastases from uterine leiomyosarcoma.

Authors/ year	Age at uLMS diagnosis	Adjuvant treatment after surgery of primary tumor	Interval from diagnosis of primary lesion to brain metastasis (months)	Site	Surgery	Adjuvant treatment after cranial surgery	1st line CHT	Interval from brain metastasis to death (months)
Uchino et al. (16)	49	Not performed	60	Frontal bone	R0 resection	Adriamycin, Vincristine, Cisplatin	No	24
Yip et al. (17)	62	CHT (schedule not specified)	15	Left parietal bone	R0 resection	Not performed	No	4 (not uLMS-related death)
Present report	38	Epirubicine—Ifosfamide	18	Right temporal—occipital bone	R1 resection	Radiation therapy (3,500 cGy in five fractions of 700 cGy)	No	NA

uLMS, uterine leiomyosarcoma; CHT, chemotherapy; R0, radical surgery, with no cancer cells seen microscopically at the resection margin; R1, cancer cells present microscopically at the resection margin (microscopic positive margin); NA, not available; cGy, centiGray.