TABLE 2.
Freeze drying of MPA-LNP using various cryoprotectants at a fixed concentration (5%, w/w).
| Cryoprotectants | Initial size | With freeze drying |
| Mannitol | ||
| Size (nm) | 183.40 ± 12.62 | 185.23 ± 13.42 |
| Ri | 1.01 ± 0.06 | |
| RS | *** | |
| Sucrose | ||
| Size (nm) | 183.40 ± 12.62 | 243.92 ± 14.56 |
| Ri | 1.33 ± 0.14 | |
| RS | * | |
| Trehalose | ||
| Size (nm) | 183.40 ± 12.62 | 212.74 ± 19.84 |
| Ri | 1.16 ± 0.12 | |
| RS | * |
Ri, redispersibility index; RS, reconstitution score, ***redispersible within 20 s with mere mixing, *reconstitution requires high shear overtaxing for 2 min. Values are presented as mean ± SD (n = 3).