TABLE 3A.
Freeze drying of MPA-LNP using mannitol at different concentrations.
| Cryoprotectant | Initial size | With freeze drying |
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| Concentration (%, w/w) | |||||
| Mannitol | 0 | 2.5 | 5 | 10 | |
| Size (nm) | 183.40 ± 12.62 | ND | 225.58 ± 6.4 | 188.90 ± 13.42 | 187.06 ± 14.21 |
| Ri | – | ND | 1.23 ± 0.11 | 1.03 ± 0.06 | 1.12 ± 0.08 |
| RS | – | * | ** | *** | *** |
Ri, redispersibility index; RS, reconstitution score, ***redispersible within 20 s with mere mixing, ** redispersible within 1 min, ND-not determined due to incomplete redispersion of cake. *Reconstitution requires high shear vortexing for 2 min, but the cake was not completely redispersed. Values are presented as mean ± SD (n = 3).