TABLE 5.
Pharmacokinetic parameters of LPN upon i.p. administration in rats.
| Parameters | MPA | MPA-LNP | MPA + QC | MPA-LNP + QC-LNP |
| AUC (ng/mL⋅h) | 11533.79 ± 869.5 | 23768.88 ± 1395 | 12478.21 ± 734.2 | 31865.65 ± 2184.5 |
| Cmax (ng/mL⋅h) | 979.3 ± 93 | 1145.29 ± 56.5 | 1004.38 ± 82.5 | 1487.39 ± 103.4 |
| T1/2 (h) | 13.07 ± 1.1 | 22.06 ± 1.6 | 13.79 ± 0.98 | 25.42 ± 2.4 |
| MRT | 18.16 ± 1.92 | 28.88 ± 2.4 | 18.84 ± 1.2 | 35.13 ± 2.4 |
AUC, area under curve; Cmax, maximum drug concentration; T1/2, time to reach half of maximum plasma concentration; MRT, mean retention time.