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. 2020 Jun 16;10:915. doi: 10.3389/fonc.2020.00915

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Copyright © 2020 Nie, Qian, Shi, Li, Peng, Ding, Zhang, Zhang, Xu, Lv, Wang, Friess, Kong, Zou and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High expression of ALDH1A3 is correlated with poor prognosis in PDAC. (A) The expression of ALDH1A3 increased in pancreatic cancer tissue compared to adjacent normal pancreatic tissue by Oncomine dataset analysis. (B) ALDH1A3 immunostaining signals were primarily detected mainly in cytoplasm, as well as in stroma partly. Bar:20 μm. (C) High expression of the ALDH1A3 in cancer tissues was associated with shorter overall survival time in the PDAC patients (p = 0.0023). (D) The ALDH1A3 expression levels were significantly associated with tumor size (p = 0.0228) and distant metastasis (p = 0.0315).