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. 2020 Jun 16;10:915. doi: 10.3389/fonc.2020.00915

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Copyright © 2020 Nie, Qian, Shi, Li, Peng, Ding, Zhang, Zhang, Xu, Lv, Wang, Friess, Kong, Zou and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ALDH1A3 promotes migration in vitro and metastasis in vivo. (A) ALDH1A3 expression was detected in six human pancreatic cancer cell lines at mRNA and protein levels. (B) The overexpression of ALDH1A3 in monoclonal cells (named as M24 and M31) at mRNA and protein levels. (C) The overexpression of ALDH1A3 in PANC-1 cells increased the number of migrated cells in transwell assay at 24 h after cell seeding. (D) Transfection efficiency of the lentiviral vector expressing shRNAs targeting ALDH1A3 in HPAC cells at mRNA and protein levels. (E) Knock-down of ALDH1A3 in HPAC cells reduced the area proportion of metastatic lesions in the largest section of each lung sample 5 weeks after cell injection.