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. 2020 Jun 16;7:101. doi: 10.3389/fmolb.2020.00101

FIGURE 2.

FIGURE 2

Temperature response model of Borrelia burgdorferi. An environmental signal activates Hk2 membrane protein that phosphorylates and activates Rrp2. Together with RNP and σ54, they facilitate transcription of rpoS. The mRNA is stabilized by the joint action of DsrABb (expressed upon temperature increase to host conditions) and Hfq, and the messenger is translated into protein. RpoS regulates the transcription of ospC, which product is displayed on the OuM. CyM, Cytoplasmic membrane; OuM, Outer membrane; PG, peptidoglycan; RNP, RNA Polymerase; SD, Shine-Dalgarno. Black thick arrows indicate flow of a biological process, e.g., protein translation. Green thick arrows indicate activation. References: Burtnick et al., 2007; Lybecker and Samuels, 2007; Lybecker et al., 2010; Radolf et al., 2012; Steere et al., 2016.