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. 2020 Jun 16;10:968. doi: 10.3389/fonc.2020.00968

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Copyright © 2020 Marks, Gartrell, El Asmar, Boboila, Hart, Lu, Pan, Yu, Hibshoosh, Guo, Andreopoulou, Wiechmann, Crew, Sparano, Hershman, Connolly, Saenger and Kalinsky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MK-2206 inhibition associated with greater expression of IGF-1R. IGF-1R expression was found to be significantly higher in the surgical specimens from the MK-2206-treated (red) vs. control (blue) patients (p = 0.02).