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. 2020 Jun 16;8:438. doi: 10.3389/fcell.2020.00438

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Copyright © 2020 Zhang, Wang, Ding, Zhang, Xu, Xu, Zheng and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The organization and distributions of migrasomes. Migrasome, which is an extracellular membrane-bound vesicular structure and includes cytosolic proteins and small vesicles in the cavity, is organized by TSPANs, cholesterol, and integrins. The matching of specific integrin-ECM pairs determine when and where migrasome can be generated in vivo. They are distributed in human blood and stroke specimens; in mouse brain and eye, rat lung, rat/mouse intestine; in zebrafish embryo. They are also found in numerous cancer cells, such as MDA-MB-231, SKOV-3, HCT116, SW480, MGC803, B16; in normal rat or mouse cells, including NRK, NIH3T3, mouse embryonic stem cells, hippocampal neurons and bone marrow-derived macrophages, and microglia; and in HaCaT in vitro.