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. Author manuscript; available in PMC: 2020 Jun 23.
Published in final edited form as: Cell Rep. 2020 Apr 28;31(4):107569. doi: 10.1016/j.celrep.2020.107569

Figure 3. Plasma Cytokine and Chemokine Levels during Early Acute, Late Acute, and Convalescent ZIKV Infections Are Differentially Expressed and Reveal a Central Role for Monocytes.

Figure 3.

(A) Heatmap representation of the average protein expression of significant changes (FDR < 0.05) of cytokine levels (pg/mL) over time. The color of the heatmap in each row is based on Z score values calculated by centering and scaling the data by standard deviation using the formula (X m)/SD), where X is individual values, and m is the mean of the row.

(B) Estimated lsmean and 95% CI are shown for selected cytokines. Asterisks above the CI bars represent significance of the changes from late-acute or convalescent to early-acute phase (n = 89). The adjusted p value is shown as *FDR < 0.05, **FDR < 0.01, ***FDR < 0.001.

See also Figures S4 and S5 and Table S1.