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. 2020 Jun 16;14:461. doi: 10.3389/fnins.2020.00461

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Copyright © 2020 Qu, Song, Shen, Xu, Li, Qu, Li and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of Mfsd2a overexpression on BBB tight junctions and vesicular transcytosis in the rat hippocampal CA1 region. (A–E) The expression of BBB permeability-related proteins, including Mfsd2a, ZO-1, claudin-5, and occludin in each group. *P < 0.05, **P < 0.01, vs. the sham group; ^#P < 0.05, ^##P < 0.01, vs. the 2VO + control AAV group; n = 6 per group. (F) Representative microphotograph of the ultrastructure of BBB in the hippocampal CA1 region of rats. Scale bar = 500 nm (the upper four pictures); scale bar = 150 nm (the lower four pictures). (G) Quantification of vesicular density of six comparable-sized vessels (4–5 μm lumen) in each rat. *P < 0.05, **P < 0.01, vs. the sham group; ^#P < 0.05, ^##P < 0.01, vs. the 2VO + control AAV group; n = 3 per group. The black arrow refers to vesicles in endothelial cells, and the red arrow refers to tight junctions. L, lumen; EC, endothelial cell.