Table 4.
Summary effects from the overall analyses of case-control association studies for genetic variants associated with fracture occurrence risk in physically active participants including only good and moderate quality studies with sex sub-groups.
| Genetic variant and risk comparison model | Sample size | Test of Heterogeneity | Test of overall association | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Participants | Studies | Overall | Between sub-groups | FE/RE | OR (95% CI) | P | |||
| Fracture/Control (risk model frequency) | I2 | P | I2 | P | |||||
| COL1A1 Sp1 (rs1800012) | |||||||||
| Allele Contrast: T | 561 (21%)/1,878 (21%) | 3 | 36% | 0.20 | 57% | 0.10 | RE | 0.95 (0.66–1.36) | 0.77 |
| Recessive: TT+TG | 333 (33%)/1,101 (33%) | 3 | 33% | 0.22 | 54% | 0.11 | RE | 0.96 (0.65–1.42) | 0.84 |
| Homozygote Contrast: TT | 333 (1.8%)/1,101 (3%) | 3 | 0% | 0.53 | 0% | 0.47 | FE | 0.73 (0.28–1.91) | 0.53 |
| VDR BsmI (rs1544410) | |||||||||
| Allele Contrast: T | 179 (68%)/1,405 (77%) | 2 | 41% | 0.18 | 0% | 0.93 | RE | 0.96 (0.59–1.56) | 0.87 |
| Recessive: TT+TG | 118 (75%)/915 (83%) | 2 | 0% | 0.45 | 0% | 0.90 | FE | 1.00 (0.62–1.62) | 1.00 |
| Homozygote Contrast: TT | 118 (27%)/915 (36%) | 2 | 0% | 0.39 | 0% | 0.45 | FE | 0.93 (0.59–1.47) | 0.75 |
RE, random effects; FE, fixed effects; OR, odds ratio; CI, confidence interval. Sample size describes frequency of case and control counts for each model with risk variant frequency in parentheses. Values in bold indicate significant heterogeneity and/or associations with fracture risk.