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. 2020 Jun 16;11:1194. doi: 10.3389/fimmu.2020.01194

Figure 1.

Figure 1

Gene expression in CD14+ cord blood monocytes (A,B) and plasma inflammatory protein profiles (C,D) in term and preterm infants presented by PCA analysis (A,C) and hierarchical clustering (B,D). Principal component analysis (PCA) plots for monocyte gene expression (A) and plasma inflammatory proteins (C) indicate that term infants (blue, n = 10) are better grouped than preterm infants (red, n = 33). Heat maps with hierarchical clustering present top 500 differentially expressed genes (q < 0.008, Qlucore software; multiple t-tests with Benajmini-Hochberg multiple correction procedure) in monocytes (B) and all significantly different (q ≤ 0.049) inflammatory proteins in plasma (D). Heatmaps and hierarchical clustering are based on fpkm (fragments per kilobase million) values where each value is normalized to mean = 0 and variance = 1. Red color denotes up-regulation and blue down-regulation within a range of −2 to +2.