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. 2020 Jun 16;11:1194. doi: 10.3389/fimmu.2020.01194

Figure 5.

Figure 5

Analysis of inflammatory proteins in cord blood plasma from preterm infants based on expression levels of S100A alarmins and in relation to clinical features associated with chorioamnionitis and fetal inflammation. Heat map with hierarchical clustering demonstrates significant elevation of 13/77 inflammatory proteins analyzed by Multiplex ELISA in S100A high (red squares, n = 17) and S100A low (blue squares, n = 16) groups (q ≤ 0,049, multiple t-tests with Benajmini-Hochberg multiple correction procedure). Red squares also indicate presence of preterm labor (PTL)/preterm prelabor rupture of membranes (PPROM); exposure to histological chorioamnionitis (HCA), histological fetal inflammatory response syndrome (FIRS) and elevated CRP/IL-6 in cord blood plasma while blue squares indicate the absence of these conditions. White squares indicate missing data. Heatmaps and hierarchical clustering are based on fpkm fragments per kilobase million) values where each value is normalized to mean = 0 and variance = 1. Red color denotes up-regulation and blue down-regulation within a range of −2 to +2.