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. 2020 Jun 16;11:1194. doi: 10.3389/fimmu.2020.01194

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Copyright © 2020 Golubinskaya, Puttonen, Fyhr, Rydbeck, Hellström, Jacobsson, Nilsson, Mallard and Sävman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Results of weighted correlation network analysis of gene expression in cord blood monocytes from preterm infants. (A) The heatmap shows correlation and (significance) of the eigengenes of the modules in relation to S100A alarmin expression and clinical inflammatory conditions [preterm labor (PTL)/preterm prelabor rupture of membranes (PPROM); exposure to histological chorioamnionitis (HCA), histological fetal inflammatory response syndrome (FIRS), and elevated CRP/IL-6 in cord blood plasma]. Significant positive correlations for all traits were seen for green and yellow modules and negative correlations for the red module. (B) Visualization of the network for the top 30 hub genes in the yellow module (weight cutoff set from 0.19 to 1) with the most pronounced hub nodes marked in red and genes connected with S100A8 and S100A9 underlined.