Table 5.
Differentially expressed genes in cord blood monocytes common to high expression of S100A alarmins as well as HCA and FIRS (n = 124).
| Gene symbol | Official full name | Aliases | Corresponding protein function |
|---|---|---|---|
| ACSS2 | Acyl-CoA synthetase short chain family member 2 | ACAS2, ACECS, ACS, ACSA, AceCS1, dJ1161H23.1 | A cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation |
| ACTR3 | Actin related protein 3 | ARP3 | A major constituent of the ARP2/3 complex |
| ADAM10 | ADAM metallopeptidase domain 10 | AD10, AD18, CD156c, CDw156, HsT18717, MADM, RAK, kuz | An ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin |
| ADCK3 | Coenzyme Q8A | COQ8A; ARCA2, CABC1, COQ10D4, COQ8, SCAR9 | A mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain |
| AKAP1 | A-kinase anchoring protein 1 | AKAP21, AKAP149, AKAP84, D-AKAP1, PPP1R43, PRKA1, SAKAP84, TDRD17, AKAP1 | A member of the AKAP family, binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion |
| ALOX5 | Arachidonate 5-lipoxygenase | 5-LO, 5-LOX, 5LPG, LOG5 | A member of the lipoxygenase gene family, plays a dual role in the synthesis of leukotrienes from arachidonic acid |
| ASGR2 | Asialoglycoprotein receptor 2 | ASGP-R2, ASGPR2, CLEC4H2, HBXBP, HL-2 | A subunit of the asialoglycoprotein receptor |
| ATP6V0D1 | ATPase H+ transporting V0 subunit d1 | ATP6D, ATP6DV, P39, VATX, VMA6, VPATPD | A component of vacuolar ATPase (V-ATPase) |
| B4GALT5 | Beta-1,4-galactosyltransferase 5 | B4Gal-T5, BETA4-GALT-IV, beta4Gal-T5, beta4GalT-V, gt-V | Type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose |
| BATF | Basic leucine zipper ATF-like transcription factor | B-ATF1, SFA-2, SFA2, BATF | A nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors |
| BTAF1 | B-TFIID TATA-box binding protein associated factor 1 | MOT1, TAF(II)170, TAF172, TAFII170 | A TAF (TATA box-binding protein-associated factor), which associates with TBP (TATA box-binding protein) to form the B-TFIID complex that is required for transcription initiation of genes by RNA polymerase II |
| C17orf62 | Cytochrome b-245 chaperone 1 | CYBC1, Eros | – |
| C9orf84 | Shortage in chiasmata 1 | SHOC1; ZIP2; MZIP2; ZIP2H | – |
| CALM3 | Calmodulin 3 | CALM, CAM1, CAM2, CAMB, CaM, CaMIII, HEL-S-72, PHKD, PHKD3 | A member of a family of proteins that binds calcium and functions as a enzymatic co-factor |
| CAMK2D | Calcium/calmodulin dependent protein kinase II delta |
CAMKD | A member of the serine/threonine protein kinase family and the Ca(2+)/calmodulin-dependent protein kinase subfamily |
| CARS | Cysteinyl-tRNA synthetase 1 | CARS1, CYSRS, MGC:11246 | A class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase |
| CD177 | CD177 molecule | HNA-2a, HNA2A, NB1, NB1 GP, PRV-1, PRV1 | A glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation |
| CD63 | CD63 molecule | LAMP-3, ME491, MLA1, OMA81H, TSPAN30 | A member of the transmembrane 4 superfamily, also known as the tetraspanin family, the encoded protein is a cell surface glycoprotein that is known to complex with integrins |
| CEACAM1 | CEA cell adhesion molecule 1 | BGP, BGP1, BGPI | A member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily, mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup |
| CEACAM3 | CEA cell adhesion molecule 3 | CD66D, CEA, CGM1, W264, W282 | A member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) |
| CFL1 | Cofilin 1 | CFL, HEL-S-15, cofilin | An intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner |
| CHMP2A | Charged multivesicular body protein 2A | BC-2, BC2, CHMP2, VPS2, VPS2A | Protein belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family |
| CNNM3 | Cyclin and CBS domain divalent metal cation transport mediator 3 | ACDP3 | – |
| CPSF2 | Cleavage and polyadenylation specific factor 2 | CPSF100 | – |
| CR1 | Complement C3b/C4b receptor 1 (Knops blood group) | C3BR, C4BR, CD35, KN | A member of the receptors of complement activation (RCA) family, a monomeric single-pass type I membrane glycoprotein, mediates cellular binding to particles and immune complexes that have activated complement |
| CREB5 | cAMP responsive element binding protein 5 | CRE-BPA, CREB-5, CREBPA | Belongs to the CRE (cAMP response element)-binding protein family containing zinc-finger and bZIP DNA-binding domains, functions as a CRE-dependent trans-activator |
| CSF2RB | Colony stimulating factor 2 receptor beta common subunit | CD131, CDw131, IL3RB, IL5RB, SMDP5, betaGMR | A common beta chain of the high affinity receptor for IL-3, IL-5, and CSF |
| CYSTM1 | Cysteine rich transmembrane module containing 1 | C5orf32, ORF1-FL49 | – |
| DOK3 | Docking protein 3 | DOKL | – |
| DYRK2 | Dual specificity tyrosine phosphorylation regulated kinase 2 | Belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development | |
| EIF2AK4 | Eukaryotic translation initiation factor 2 alpha kinase 4 | GCN2, PVOD2 | A member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis |
| ERI1 | Exoribonuclease 1 | 3′HEXO, HEXO, THEX1 | – |
| EXOC6 | Exocyst complex component 6 | EXOC6A, SEC15, SEC15L, SEC15L1, SEC15L3, Sec15p | Similar to the yeast gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface, one of the components of a multiprotein complex required for exocytosis |
| EXOC7 | Exocyst complex component 7 | 2-5-3p, BLOM4, EX070, EXO70, EXOC1, Exo70p, YJL085W | A component of the exocyst complex, is required for assembly of the exocyst complex and docking of the complex to the plasma membrane |
| FAM109A | PH domain containing endocytic trafficking adaptor 1 | PHETA1; SES1; IPIP27A | A protein that localizes to the endosome and interacts with inositol polyphosphate 5-phosphatase OCRL-1 |
| FAM151B | Family with sequence similarity 151 member B | UNQ9217 | – |
| FAM20A | FAM20A golgi associated secretory pathway pseudokinase | AI1G, AIGFS, FP2747 | A protein that is likely secreted and may function in hematopoiesis |
| FCER1G | Fc fragment of IgE receptor Ig | FCRG | A high affinity IgE receptor |
| FCGR1A | Fc fragment of IgG receptor Ia | CD64, CD64A, FCRI, IGFR1 | A high-affinity Fc-gamma receptor |
| FCGR1B | Fc fragment of IgG receptor Ib | CD64b, FCG1, FCGR1, FCGR1A, FcRI, FcgammaRIa, IGFR1, IGFRB | A low affinity FcgammaRIB receptor that may play an important role in humoral immune response |
| FCGR1C | Fc fragment of IgG receptor Ic, pseudogene | FCGR1CP; CD64c; FCRIC; IGFR1; IGFRC | – |
| FKBP1A | FKBP prolyl isomerase 1A | FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE | A member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking |
| FNDC3B | Fibronectin type III domain containing 3B | FAD104, PRO4979, YVTM2421 | – |
| FXN | Frataxin | CyaY, FA, FARR, FRDA, X25 | A mitochondrial protein which belongs to the FRATAXIN family, participates in regulating mitochondrial iron transport and respiration |
| GBA | Glucosylceramidase beta | GBA1, GCB, GLUC | A lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide |
| GFRA2 | GDNF family receptor alpha 2 | GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2 | A member of the GDNF receptor family, a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for GDNF and NTN, mediates activation of the RET tyrosine kinase receptor |
| GK | Glycerol kinase | GK1D, GK | Protein belongs to the FGGY kinase family, it is a key enzyme in the regulation of glycerol uptake and metabolism |
| GNG5 | G protein subunit gamma 5 | A member of a family of G proteins | |
| GPR84 | G protein-coupled receptor 84 | EX33, GPCR4 | – |
| GTF2A2 | General transcription factor IIA subunit 2 | HsT18745, T18745, TF2A2, TFIIA, TFIIA-12, TFIIA-gamma, TFIIAS | Factor for transcription initiation on TATA-containing class II genes |
| GUSBP3 | GUSB pseudogene 3 | GUSBP1, SMA3 | – |
| HCK | HCK proto-oncogene, Src family tyrosine kinase | JTK9, p59Hck, p61Hck | A member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages |
| HDAC1 | Histone deacetylase 1 | GON-10, HD1, KDAC1, RPD3, RPD3L1 | Belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex |
| HSD3B7 | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | CBAS1, PFIC4, SDR11E3 | A member of the short-chain dehydrogenase/reductase superfamily |
| IFNAR1 | Interferon alpha and beta receptor subunit 1 | AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC | A type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta |
| IGSF6 | Immunoglobulin superfamily member 6 | DORA | – |
| IL4R | Interleukin 4 receptor | CD124, IL-4RAA, IL4R | Encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 |
| ITGB2 | Integrin subunit beta 2 | CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 | An integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers |
| JAK3 | Janus kinase 3 | JAK-3_HUMAN, JAKL, L-JAK, LJAK, JAK3 | A member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction |
| KDM1A | Lysine demethylase 1A | AOF2, BHC110, CPRF, KDM1, LSD1 | A nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein silences genes by functioning as a histone demethylase |
| KREMEN1 | Kringle containing transmembrane protein 1 | ECTD13, KREMEN, KRM1 | A high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling |
| L3MBTL3 | L3MBTL histone methyl-lysine binding protein 3 |
MBT-1, MBT1 | A member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors, is associated with the repression of gene expression |
| LAMTOR2 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 |
ENDAP, HSPC003, MAPBPIP, MAPKSP1AP, ROBLD3, Ragulator2, p14 | Protein with suggested role in endosomal biogenesis |
| LCP1 | Lymphocyte cytosolic protein 1 | CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2 | A member of a family of actin-binding proteins plastins |
| LGALS1 | Galectin 1 | GAL1, GBP | A protein from a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions |
| LIMK2 | LIM domain kinase 2 | Belongs to a small subfamily of LIM proteins with 2 N-terminal LIM motifs and a C-terminal protein kinase domain, phosphorylates cofilin, inhibiting its actin-depolymerizing activity | |
| LITAF | Lipopolysaccharide induced TNF factor | PIG7, SIMPLE, TP53I7 | Lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene |
| LMNB1 | Lamin B1 | ADLD, LMN, LMN2, LMNB | B-type lamin protein, is a component of the nuclear lamina |
| LUC7L | LUC7 like | LUC7B1, Luc7, SR+89, hLuc7B1 | – |
| MAP3K14-AS1 | MAP3K14 antisense RNA 1 | ||
| MAP4K1 | Mitogen-activated protein kinase kinase kinase kinase 1 |
HPK1 | – |
| MARVELD1 | MARVEL domain containing 1 | GB14, MARVD1, MRVLDC1, bA548K23.8 | – |
| METTL7B | Methyltransferase like 7B | ALDI | – |
| MILR1 | Mast cell immunoglobulin like receptor 1 | Allergin-1, C17orf60, MCA-32, MCA32 | – |
| MRPL28 | Mitochondrial ribosomal protein L28 | MAAT1, p15 | A 39S subunit protein, belongs to mitochondrial ribosomal proteins |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | HMAG, MS, cblG | 5-methyltetrahydrofolate-homocysteine methyltransferase, catalyzes the final step in methionine biosynthesis |
| MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | MSR, cblE | A member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases, functions in the synthesis of methionine by regenerating methionine synthase to a functional state |
| MYO10 | Myosin X | A member of the myosin superfamily, represents an unconventional myosin | |
| MYO7B | Myosin VIIB | Is involved in linking protocadherins to the actin cytoskeleton and is essential for proper microvilli function | |
| NCF4 | Neutrophil cytosolic factor 4 | CGD3, NCF, P40PHOX, SH3PXD4 | A cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase |
| PART1 | Prostate androgen-regulated transcript 1 | NCRNA00206 | – |
| PIK3AP1 | Phosphoinositide-3-kinase adaptor protein 1 | BCAP | – |
| PIK3IP1 | Phosphoinositide-3-kinase interacting protein 1 | HGFL, TrIP, hHGFL(S) | – |
| PIM1 | Pim-1 proto-oncogene, serine/threonine kinase |
PIM | The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival |
| PLB1 | Phospholipase B1 | PLB, PLB/LIP | A membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids |
| PLSCR1 | Phospholipid scramblase 1 | MMTRA1B | – |
| PLXNC1 | Plexin C1 | CD232, PLXN-C1, VESPR | A member of the plexin family of transmembrane receptors for semaphorins |
| POLR1E | RNA polymerase I subunit E | PAF53, PRAF1 | – |
| PPM1M | Protein phosphatase, Mg2+/Mn2+ dependent 1M | PP2C-eta, PP2CE, PP2Ceta | – |
| PPP1R18 | Protein phosphatase 1 regulatory subunit 18 | HKMT1098, KIAA1949 | Protein phosphatase-1 interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates |
| PSMB7 | Proteasome 20S subunit beta 7 | Z | A member of the proteasome B-type family, it is a 20S core beta subunit in the proteasome |
| PTPN2 | Protein tyrosine phosphatase non-receptor type 2 | PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP | A member of the protein tyrosine phosphatase (PTP) family known to be signaling molecules that regulate cell growth, differentiation, mitotic cycle, and oncogenic transformation |
| RAB31 | RAB31, member RAS oncogene family | Rab22B | A small GTP-binding protein of the RAB family, participates in vesicle and granule targeting |
| RGL4 | Ral guanine nucleotide dissociation stimulator like 4 | Rgr | A protein similar to guanine nucleotide exchange factor Ral guanine dissociation stimulator |
| RHBDD2 | Rhomboid domain containing 2 | NPD007, RHBDL7 | A member of the rhomboid family of membrane-bound proteases |
| RHOG | Ras homolog family member G | ARHG | A member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades |
| S100A11 | S100 calcium binding protein A11 | HEL-S-43, MLN70, S100C | A member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs |
| SBNO2 | Strawberry notch homolog 2 | KIAA0963, SNO, STNO | – |
| SERPINA1 | Serpin family A member 1 | A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT, nNIF | A serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator |
| SIPA1L2 | Signal induced proliferation associated 1 like 2 | SPAL2, SPAR2 | A member of the signal-induced proliferation-associated 1 like family containing a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper |
| SLC2A3 | Solute carrier family 2 member 3 | GLUT3 | – |
| SNX20 | Sorting nexin 20 | SLIC1 | – |
| SRF | Serum response factor | MCM1 | A member of the MADS box superfamily of transcription factors, stimulates both cell proliferation and differentiation |
| SRP14 | Signal recognition particle 14 | ALURBP | – |
| ST3GAL2 | ST3 beta-galactoside alpha-2,3-sialyltransferase 2 | Gal-NAc6S, SIAT4B, ST3GALII, ST3GalA.2 | A type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates |
| TCAIM | T cell activation inhibitor, mitochondrial | TOAG1; TOAG-1; C3orf23 | – |
| TESC | Tescalcin | CHP3, TSC | – |
| TMBIM6 | Transmembrane BAX inhibitor motif containing 6 |
BAXI1, BI-1, TEGT | – |
| TMEM117 | Transmembrane protein 117 | – | |
| TMEM120A | Transmembrane protein 120A | NET29, TMPIT | – |
| TNFRSF1A | TNF receptor superfamily member 1A | CD120a, FPF, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR55, TNFR60, p55, p55-R, p60 | A member of the TNF receptor superfamily of proteins |
| TPRKBP2 | TP53RK binding protein pseudogene 2 | – | |
| TYSND1 | Trypsin domain containing 1 | NET41 | A protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome |
| UBE2L3 | Ubiquitin conjugating enzyme E2 L3 | E2-F1, L-UBC, UBCH7, UbcM4 | A member of the E2 ubiquitin-conjugating enzyme family, participates in ubiquitination of proteins |
| UFD1L | Ubiquitin recognition factor in ER associated degradation 1 | UFD1L | The encoded protein forms a complex with nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins |
| URB1 | URB1 ribosome biogenesis homolog | C21orf108, NPA1 | – |
| WDFY3 | WD repeat and FYVE domain containing 3 | ALFY, BCHS, MCPH18, ZFYVE25 | A phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy |
| WDFY3-AS1 | WDFY3 antisense RNA 1 | ncRNA | |
| WDR59 | WD repeat domain 59 | CDW12, FP977, p90-120 | – |
| VOPP1 | VOPP1 WW domain binding protein | ECOP, GASP, WBP1L2 | – |
| ZBTB41 | Zinc finger and BTB domain containing 41 | FRBZ1, ZNF924 | – |
| ZNF337 | Zinc finger protein 337 | A zinc finger domain containing protein | |
| ZNF438 | Zinc finger protein 438 | – | |
| ZNF529 | Zinc finger protein 529 | – |
Lists of differentially expressed genes were created using Qlucore Omics Explorer v3.4. Description of the genes (Gene Official Full Name, Aliases, info about corresponding protein transcript) are adapted from Gene ncbi database https://www.ncbi.nlm.nih.gov/gene/.