Figure 2.

A single treatment with α-Ly6G restores spatial short-term memory one day after injection in APP/PS1 mice as old as 14–15 months of age. (a) Tracking of mouse nose location from video recording during training and trial phases of OR task taken one day after administration of α-Ly6G or Iso-Ctr antibodies in APP/PS1 mice at 14–15 months of age. (b) Preference score for OR of APP/PS1 and WT mice at baseline and at one day after a single administration of α-Ly6G or Iso-Ctr antibodies at different ages. (c) Preference score one day after treatment for individual animals from each group across age. Black line shows the median trend for each group. Blue shading indicates treatment at that time point with α-Ly6G, while no shading indicates treatment with Iso-Ctr antibodies. (d) Time spent at the replaced object measured over 3 min for APP/PS1 and WT mice at baseline and at one day after a single administration of α-Ly6G or isotype control antibodies across animal age. (Group 1 (blue) APP/PS1: 10 mice; Group 2 (red) APP/PS1: 10 mice; Group 3 (green) WT: 11 mice; D’Agostino-Pearson was performed for normality followed by one-way ANOVA and Holms-Sidak’s multiple comparison; *p < 0.05, **p < 0.01, ***p < 0.001. All boxplots are defined as: whiskers extend 1.5 times the difference between the value of the 75th and 25th percentile, median = black line and mean = red line.)