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. 2020 Mar 24;40(7):1381–1401. doi: 10.1177/0271678X20911331

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Figure 6. — The relation between pericytes and EVs: Pericytes can be donors or recipients of EVs. (a) As a recipient, pericytes may receive EVs from multiple cell sources. Pericytes can engulf various ECs-derived EVs that contain miRs, and then migrate, proliferate, and promote angiogenesis. (b) As a donor, pericytes secrete vesicles context-dependently. Under normoxic conditions, pericytes may secrete exosomes that contain antiangiogenic factors (Exosomes-antiangiogenic) to maintain vascular stability. In hypoxia, pericytes secrete exosomes with proangiogenic factors (exosomes-proangiogenic). Stimulated by PDGF-BB, pericyte-derived MVs carry growth factors (MVs-growth factors), whereas inflamed by LPS, pericyte-derived MVs contain proinflammatory cytokines (MVs-proinflammatory). Conversely, pericytes may negatively regulate the transportation of EVs. Stimulated by PDGF-BB, pericytes secrete scavenger MGF-E8 that promotes phagocytes engulfment of MVs produced by cells that are coated with phosphatidylserines.