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. 2020 Jun 16;11:1185. doi: 10.3389/fimmu.2020.01185

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Copyright © 2020 Zhai, Bell, Ladomersky, Lauing, Bollu, Sosman, Zhang, Wu, Miller, Meeks, Lukas, Wyatt, Doglio, Schiltz, McCusker and Wainwright.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The tryptophan (Trp)→ kynurenine (Kyn) metabolic pathway. The majority of dietary tryptophan (95%) is metabolized via the TrpKyn pathway (red arrows). A minor pathway that converts tryptamine into kynuramine is also included. Metabolites capable of crossing the blood brain barrier (BBB) are underlined. IDO and TDO are highlighted in black boxes. KMO, kynurenine 3-monooxygenase; KYNU, kynureninase; KAT, kynurenine aminotransferase (I, II, III); 3-HAO, 3-hydroxyanthranilate 3,4-dioxygenase; ACMSD: 2-amino-3-carboxymuconate semialdehyde carboxylase; QPRT, quinolinic-acid phosphoribosyl transferase.

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