Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 16;11:579. doi: 10.3389/fphys.2020.00579

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Hosotani, Kawasaki, Hasegawa, Wakasa, Hoshino, Takahashi, Ueda, Takaya, Iwasaki and Watanabe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Relationship of gene expression levels in the various stages to fibrotic area in the muscle. (A) Hypoxia-adaptive gene expression including hypoxia inducible factor 1 subunit alpha (HIF1A) and vascular endothelial growth factor A (VEGFA). (B) Mitochondrial dynamics-related gene expression including mitofusion 1, 2 (MFN1, 2), OPA1, mitochondrial dynamin-like GTPase (OPA1), and dynamin-related protein 1 (DRP1). (C) Autophagy-/mitophagy-related gene expression including microtubule-associated protein 1 light chain 3 alpha, beta (MAP1LC3A, B) and parkin RBR E3 ubiquitin protein ligase (PARK2). Data represent the means ± SE [stage I (n = 6), stage II (n = 5), stage III (n = 6), stage IV (n = 5), stage V (n = 9), and stage VI (n = 4), Tukey test (P < 0.05)].