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Unbiased whole-genome RNA sequencing and functional analyses of circulating monocytes of individuals with elevated Lp(a) show a strong pro-inflammatory and pro-migratory profile. Only potent Lp(a) reduction demonstrated a profound reduction in the reported pro-inflammatory and pro-migratory profile, as opposed to modest Lp(a) reduction, indicating the promising potential of potent Lp(a)-lowering strategies in reducing cardiovascular risk.
