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Low-density lipoprotein (LDL) and atherobiology. Summary of the principal mechanisms underlying the entry, retention, and accumulation of LDL particles in the artery wall, and subsequent LDL-driven downstream events that are central to the complex pathogenesis of atherothrombosis. Intermediate fatty streak lesions are characterized by subintimal accumulation of macrophage foam cells. AGE, advanced glcation end-products; LDL-C, LDL-cholesterol; MMPs, matrix metallopeptidases
