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. 2020 Jun 16;8:385. doi: 10.3389/fcell.2020.00385

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Copyright © 2020 Abooshahab, Hooshmand, Razavi, Gholami, Sanoie and Hedayati.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolome view of pathway impact analysis obtained from differential metabolites in PTC (A) and differential metabolites in MNG (B). The color and size of each circle is based on p-values (yellow: higher p-values and red: lower p-values) and pathway impact values (the larger the circle the higher the impact score) calculated from the topological analysis, respectively. Pathways were considered significantly enriched if p < 0.05, impact 0.1 and number of metabolite hits in the pathway >1. PTC; papillary thyroid carcinoma, MNG; multinodular goiter.